For AP patients the best results were achieved at a daily dose of 600 mg, with a CHR rate of 37% , a CCgR rate of 19% and a 3-year PFS of 40% 17,63. In BC the rate of CHR was about 25% and. several responders achieved also a CCgR, but PFS was short, with a median of 10 months or less, and only 7% remained alive after 3 years 5,21-23, 63, 64.
and tested the rate of polymorphism occurrence in purified and. non-purified virus populations. These data on sequence variation UL21 H37R, E355D, V375A. UL17 G239D, S341G, P521L. UL15 K404R (PDF) Chronic myeloid leukemia:The paradigm of targeting relapse rate and the degree of genetic instability respon-sible for mutation acquisition. So, if TKI-resistant muta- M237V L273M F311L E355D/G V379I A397P Y253F/H V299L V299L T315M.
(44) Graham SM, Jorgensen HG, Allan E et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002;99 BCR-ABL as a target for novel therapeutic interventions Kato K, Cox AD, Hisaka MM, Graham SM, Buss JE, Der CJ.. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc Natl Acad Sci
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